Dynamic density functional theory of multicomponent cellular membranes

We present a continuum model trained on molecular dynamics (MD) simulations for cellular membranes composed of an arbitrary number lipid types. The is constructed within the formalism dynamic density functional theory and can be extended to include features such as presence proteins membrane deformations. This framework represents paradigm shift by enabling that access length scales order microns time seconds, all while maintaining near fidelity underlying MD models. These are significant accessing biological processes associated with signaling pathways cells. Membrane interactions RAS, protein implicated in roughly 30% human cancers, considered application. Simulation results presented verified simulations, implications this new capability discussed.